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Miscarriage rate per couples after cleavage stage versus blastocyst stage embryo transfer (Glujovsky et al, 2013)
• Systematic review and meta‐analysis of 14 randomized controlled trials
• No heterogeneity, I‐squared = 0%
• Pooled Odds Ratio (95% CI) = 1.14 (0.84 to 1.55)
Miscarriage rate and number of oocytes retrieved (Sunkara et al, 2014)
• Miscarriage rates were 20.0% (1‐3 oocytes), 15.5% (4‐9 oocytes), 13.8% (10‐14 oocytes), 13.1% (15+ oocytes)
• Adjusting for age reduced effect of oocyte numbers
Prevention of miscarriage in IVF
• Preimplantation Genetic Screening (Forman et al, 2013)
• Improves implantation rates
• Reduces miscarriage rates
• Weight loss
• Gestational carrier / dygesterone for recurrent miscarriage
• Future research...
• Endometrial microbiome in IVF patients
• Presence of dysbiotic or pathogenic bacteria populations has been proposed as an emerging cause of repeated implantation failure or recurrent miscarriage
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PRECONGRESS COURSE 06 I VIENNA, AUSTRIA – 23 JUNE 2019 11