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Sperm aster
After entering the egg,
the sperm centriole nucleates the first microtubules in the zygote
The centrosome generated after fertilization is a mix of paternal and maternal components
Navara et al 1994 Dev Biol Nakamura et al 2001 BOR
Delivery of sperm RNAs & transcription factors
Highly condensed sperm nucleus thought transcriptionally inactive (Kierszenbaum & Tres 1975)
 Sperm‐specific human RNAs shown to be delivered to the oocyte on fertilization (Ostermeier, et al 2004)
Sperm factors involved in fertilisation:
PLCζ (Saunders et al 2002)
PAWP (postacrosomal sheath WW domain binding protein) (Wu et al. 2007)
 truncated c‐Kit tyrosine kinase (Sette et al 2002) CatSper (Williams et al 2015)
Izumo1 (Inoue et al. 2005)
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PRECONGRESS COURSE 02 I VIENNA, AUSTRIA – 23 JUNE 2019 39