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Destruction of sperm mitochondria
 Sperm mitochondria, tail and other remnants ubiquitylated – marked for destruction by oocyte cytoplasmic factors
Krawetz 2005, Nature Reviews
Summary (1)
 Successful fertilisation relies on accurately coordinated and interdependent processes of egg and sperm origin.
 Oocyte major contributor to fertilisation and embryo development
 Both female and male genomes are required for complete embryogenesis
 Major reorganisation of oocyte cytoplasmic organelles and cytoskeleton
 Oocyte activation main event of fertilisation process – PLCζ sperm‐derived activating factor
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