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Summary (2)
Two blocks against polyspermy:
o Modification of the oolemma (requires fusion of sperm‐egg
membranes)
o Exocytosis of cortical granules (modification of ZP)
 Juno (egg) and Izumo (sperm) implicated in the recognition and/or fusion process, and affect fertility.
 Worth looking beyond paternal genome and consider the paternal cellular contribution at fertilization.
 Centriole derived from sperm creates sperm aster – migration of PN
 Sperm derived RNAs and proteins important for fertilisation
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