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Centrosomes
 Organelles (microtubule cylinders) that act as MTOCs
 Form the two poles of the mitotic spindle, which separates
chromosomes to daughter cells during cell division
Centrosomes contain
o a pair of centrioles
o Pericentriolar material (PCM)
(γ‐tubulin, pericentrin, NuMA)
Schatten & Stearns 2015
Centriole elimination before oocyte meiosis
 In oocytes, centrioles are lost after pachytene stage
 Drosophila, Caenorhabditis elegans, Xenopus, chicken,
rodents, cow, sheep, humans and all other mammals.
 Unclear mechanism
 Oocyte meiosis is acentrosomal. Female meiotic spindles are assembled in a centrosome‐independent manner
 PCM proteins are not eliminated ‐ role in establishment and maintenance of the bipolar spindle apparatus
Dumont & Desai 2012 Schuh & Ellenberg 2007 Hoyer‐Fender 2011
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