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Past, current and future perspectives in non-obstructive azoospermia

Precongress Course 1

Andrology    Special Interest Group Andrology


Course coordinators
Nathalie Rives (France), Francesco Lotti (Italy)

Course type
Advanced

Course description
Non-obstructive azoospermia (NOA) is the most severe form of spermatogenesis impairment in infertile males. Surgical testicular sperm extraction and assisted reproductive technology offer NOA patients the possibility of becoming genetic fathers. The management of NOA patients at the clinical, biological and ultrasound levels will be presented during this course. It will also discuss non-invasive predictors of sperm retrieval, genetics diagnosis of NOA, molecular mechanisms involved in spermatogenesis impairment and perspectives on improving sperm retrieval.

Target audience
Andrologists, urologists, embryologists, reproductive endocrinologists, clinicians in reproductive medicine, basic scientists in reproductive medicine, paramedicals, nurses, midwives

Educational needs and expected outcomes 

  • To be able to perform the clinical, biological and ultrasound examination of infertile males with non-obstructive azoospermia
  • To be able to understand the main genetic analyses proposed in case of non-obstructive azoospermia
  • To be able do identify the main predictors of sperm retrieval in non-obstructive azoospermia
  • To be able to understand the future perspectives in the treatment of non-obstructive azoospermia

At the end of the course, the participants should be able to:

  • Acquire knowledge on clinical, biological and ultrasound evaluation of infertile males with non-obstructive azoospermia
  • Acquire knowledge on past and future predictors of successful sperm retrieval
  • Acquire knowledge on genetics exploration of non-obstructive azoospermia
  • Acquire novel knowledge on mechanisms involved in spermatogenesis impairment in non-obstructive azoospermia
  • Acquire knowledge of current and future methods to increase the chances of sperm retrieval in non-obstructive azoospermia


Innovative aspects of the course
The course will present up-to-date knowledge in the management of non-obstructive azoospermia from the clinical aspects to the molecular mechanisms involved in non-obstructive azoospermia.

Programme





Sunday 29 June 2025

Session 1: Management of non-obstructive azoospermia (NOA)
09:00 - 09:30
Clinical and ultrasound evaluation of NOA males
Francesco Lotti, Italy
09:30 - 10:00
Predictors of successful sperm retrieval in NOA
Nathalie Rives, France
10:00 - 10:30
Discussion
10:30 - 11:00
Coffee break
Session 2: Omics in NOA
11:00 - 11:30
Genetics of non-obstructive azoospermia: from karyotyping to whole-exome sequencing
Csilla Gabriella Krausz, Italy
11:30 - 11:45
Discussion
11:45 - 12:15
Mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia
Ryan Flannigan, U.S.A.
12:15 - 12:30
Discussion
12:30 - 13:30
Lunch break
Session 3: From sperm retrieval to ICSI outcome in NOA
13:30 - 14:00
Testicular sperm extraction (TESE) versus micro-TESE
Sandro Esteves, Brazil
14:00 - 14:15
Discussion
14:15 - 14:45
ICSI outcome and progeny health using fresh or frozen-thawed testicular spermatozoa
Herman Tournaye, Belgium
14:45 - 15:00
Discussion
15:00 - 15:30
Coffee break
Session 4: How to improve sperm retrieval in NOA?
15:30 - 15:50
Medical treatment in NOA to improve sperm retrieval
Manuela Simoni, Italy
15:50 - 16:00
Discussion
16:00 - 16:20
Germline genomic editing and non-obstructive azoospermia
Pierre Ray, France
16:20 - 16:30
Discussion
16:30 - 17:00
Discussion of all content of day