Page 34 - ESHRE2019

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Human and Mouse early embryo development
HUMAN
Amniotic Cavity/lumen
Embryo Yolk sac
Post-implantation Embryonicday0 1 2 3 4 5 6 14
MOUSE
EPI ExE Proamniotic EPI Cavity/lumen
VE Post-implantation
EPI = Epiblast, VE = Visceral Endoderm, ExE = Extra-embryonic Ectoderm
Elimination of aneuploid cells from epiblast
Proportion of cells in EPI relative to diploid-diploid
Diploid
Diploid
Diploid
2.0 ns 1.5
1.0
0.5
0.0
Diploid Diploid Diploid Aneuploid
Diploid cells regulate mosaic EPI number by early post-implantation
Aneuploid
Reversine
EPI mTomato H2B-GFP
Diploid – Aneuploid mosaic chimera
EPI cells (%) 49.99
19.67
Preferential elimination of aneuploid cells by early post-implantation
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