Page 36 - ESHRE2019

Mosaic epiblast development during implantation in vitro Diploid - Diploid
chimera
Diploid - Aneuploid mosaic chimera
Immunosurgery
72 hours
Reversine Diploid - Diploid
Time
Diploid - Aneuploid
Time
EPI cells (%) 61.3
Diploid
Diploid 27.8 Aneuploid
Diploid
Aneuploid cells are preferentially eliminated from mosaic epiblast during implantation
Apoptosis of aneuploid cells in mosaic epiblast during implantation
Reduced in vitro culture system (without TE)
Diploid - Aneuploid
Reversine
Diploid - Aneuploid
Time
mTomato H2B-GFP mTomato H2B-GFP mTomato H2B-GFP
34
31