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2.0 1.6 1.2 0.8 0.4 0.0
7 ns
What mediates the apoptosis of aneuploid cells in embryos?
p53 mediates apoptosis of aneuploid cells
p53: Tumor-suppressor
It is a transcription factor induced by stress, can promote cell cycle arrest and apoptosis
+/-Reversine
Diploid
* *5
p53 cyclinG1 p21
bcl2
0
Diploid
Aneuploid
Aneuploid cells upregulate p53 pathway
p53 knockdown suppresses apoptosis
Aneuploid
Control siRNA p53 siRNA
p53 siRNA/Control siRNA +/-Reversine SYTOX/KSOM
Relative mRNA expression
Number of dying cells in ICM
* 6**
*
l
33
4* 3
2
1