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Lupus unit, St Thomas.
New Engl J Med 1995; 332: 993-7
Comparison of two intensities of warfarin Crowther et al. New Engl J 2003; 349: 1133-8
• Randomised, double-blind study
• 114 patients randomised to INR 2-3 & 3-4 for 2.7 years
• Thrombosis rate 10.7% & 3.4% 9 no significant difference
• Bleeding rate: no difference
• Recommended INR target of 2-3
• BUT
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