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Comparison of two intensities of warfarin Crowther et al. New Engl J 2003; 349: 1133-8
• Patients were excluded if previous warfarin failure: recurrent thromboses at INR 2-3
• Only 20% of patients had previous arterial thrombotic events events
• At high intensity INR, treatment failures occurred usually when INR <3.0, yet analysed according to intention to treat.
• 10% were also taking aspirin
Our management of thrombotic APS in 2018
Previous venous thrombosis: Target INR 2-3
Previous arterial thrombosis & recurrent VTE:
Target INR 3-4
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