Page 70 - ESHRE2019

Sperm Motility
Zinc Inhibits Sperm Motility
Zona Penetration OvstNull Eggs
60 50 40 30 20 10
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Rapid
Medium Slow
Ctrl MgSO4 ZnSO4
Static
70 60 50 40 30 20 10 0
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Current Model o*f Fe*rtiliz*ation*
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Control Media
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MgSO4
50 (M) ZnSO4
Dev Cell 46:627, 2018
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• The N-terminus of ZP2 is the zona pellucida ligand for capacitated sperm binding.
• Neither N- nor O-glycans are essential for gamete recognition
• Post-fertilization cortical granule exocytosis
• Releases Zn+2 which promotes a transient block to zona
penetration by impairing sperm motility
• Releases ovastacin that cleaves ZP2 after which sperm do not bind to the zona pellucida
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Sperm in PVS
Sperm (%)