Page 60 - ESHRE2019
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Detection of risk factors for increased sperm DNA fragmentation
• Epidemiology
• Repeated IVF/ICSI failure
• Preimplantation embryonic development failure • Recurrent miscarriage
• Heat exposure
Occupational, Recreational, Sport, Obesity, Varicocele, Cryptorchidism
• Leukocytospermia/genital tract infection/inflammation (epididymitis)
• General illness, recurrent fever, infection (cystic fibrosis...), chronic inflammatory
disease
• Toxins
Smoking, Pesticides ...
Chemotherapy, Radiotherapy
• Chromosomal abnormalities
• Hypospermatogenesis
• Aging
• Gene polymorphism of the physiological anti‐oxidant system
In clinical practice
• Detecting risk factors for increased sperm DNA fragmentation
• Measuring sperm DNA fragmentation index
• Eliminating risk factors
• Antioxidant treatment
• Checking DNA fragmentation index before ART
• Selecting sperms with lowest DFI for ART.
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