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Sperm DNA Fragmentation is observed in several causes of male infertility
Hypospermatogenesis, incorrectly matured spermatozoa
(Gil‐Guzman et al., 2001; Gomez et al., 1996).
Chromosome structural abnormalities: Reciprocal translocations,
Robertsonian translocations, Pericentric inversions Aging (Das et al., 2013; Hammiche et al., 2011; Rybar et al., 2011).
Prolonged sexual abstinence (Gosalvez et al 2011)
Genetic variation in DNA repair pathways, Detoxification pathways, Antioxidant genes (Yu & Huang, 2015)
In clinical practice
• Detecting risk factors for increased Sperm DNA fragmentation
• Measuring sperm DNA fragmentation index
• Eliminating risk factors
• Antioxidant treatment
• Checking DNA fragmentation index before ART
• Selecting sperms with lowest DFI for ART.
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PRECONGRESS COURSE 01 I VIENNA, AUSTRIA – 23 JUNE 2019 57
