Page 148 - ESHRE2019

NEURO-DEVELOPMENT
Risk for autism
Swedish cohort 30 959 ART (1.2%), 2.5 million SC, follow up 10 years
1.5% of children autistic disorders conceived by IVF ART vs SC increased risk for autism
ART vs SC: RR 1.18 (0.94-1.39)
ART vs SC NOT increased in singletons
ICSI vs IVF (fresh) NOT increased in singletons
Sandin, JAMA. 2013 Jul 3;310(1):75‐84.
ESHRE 2019
26-5-2019 | 27
NEURO-DEVELOPMENT
Mental retardation
Sweden cohort 30 959 ART (1.1%), 2.5 million SC, follow up 10 years
1.1% of children with mental retardation conceived by IVF
ART increased risk for mental retardation vs SC ART vs SC: RR 1.18 (1.01-1.36)
ART risk NOT increased in singletons
ICSI surgically extracted sperm vs IVF : increased risk RR, 4.60 (2.14-9.88)
ICSI frozen embryo’s vs IVF: increased risk
RR, 2.36 (1.04-5.36) Sandin, JAMA. 2013 Jul 3;310(1):75‐84.
ESHRE 2019
26-5-2019 | 28
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