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Important risk factor in ART vs SC for any imprinting disorder
e.a. Beckwith Wiedeman, Angelmann, Prader Willi
• Literature data 18 studies (17 cohort and 1 case control)
OR 3.67 (1.39-9. 74) more risk in ART
• Insufficient evidence for association between ART and methylation errors in other genes
• Type of anomalies: rare imprinting errors leading to diseases
• Heterogeneity in type of fertility treatments, imprinted regions studied...No final conclusion, better studies needed
ESHRE 2019
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CANCER RISK
Author year
Williams 2013
Sundh 2014
Lerner‐Geva 2017
Williams 2018
Country/year
UK
Nordic countries 1982‐2001
Israel
UK
No of ART children
106 013
91 796
9042
12 137 Donor ART
No of cancers
108
181
21
12
Median follow up years
6.6
9.5
10.6
7.9
SIR/HR/OR
0.98 (0.81‐1.19)
1.08 (0.91‐1.27)
1.42 (0.85‐2.37) ICSI vs IVF 0.76 (0.32‐1.81)
0.83 (0.43‐1.45)
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