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PERINATAL OUTCOME
Neonatal outcome in ICSI ICSI compared to IVF
12 10 8 6 4 2 0
PTB VPTB LBW VLBW
25 IVF studies, 16 ICSI studies ICSI IVF
SGA PNM
Birth defects
Qin et al., Arch Obstet Gyn 2017
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PERINATAL OUTCOME
Malformations ART vs SC
Study
Källen et al
Davies et al
Halliday et al
Hansen et al
Pinborg et al
Klemetti et al
Ombelet et al
Källen et al
Kelley‐Quon et al
Fuji et al
Henningsen et al
Years of sampling
1982−2001
1986−2002
1991−2004
1994−2002
1995−2000
1996−1999
1997−2003
2001−2007
2006−2007
2006
1982‐2007
Adjusted OR (95% CI)
1.44 (1.32−1.57)
1.24 (1.09−1.41)
1.36 (1.19−1.55)
1.53 (1.30−1.79)
1.24 (0.97−1.58)
1.31 (1.10−1.57)
1.11 (0.08−1.58)
1.25 (1.15−1.37)
1.25 (1.21−1.39)
1.17 (0.81−1.69)
1.12 (1.08‐1.17)
Statistical significance
Yes
Yes
Yes
Yes
No
Yes
No
Yes
Yes
No
Yes
Country
Sweden
Australia (Adelaide)
Australia (Parkville)
Australia (Perth)
Denmark
Finland
Belgium
Sweden
USA (California)
Japan
Nordic countries
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