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PERINATAL OUTCOME
Malformations in ICSI ICSI compared to IVF
• Increase of 20-30% in malformation rate compared to SC well established
• Zhu, 2006: 1.39 (CI 1.23-1.57)
• Wen, 2012: 1,37 (CI 1,26-1,48)
• NodifferenceinICSIvsIVF:
• Lie, 2005: RR 1.12 (0.97-1.28)
• Wen, 2012: 1,05 (CI 0,91-1,20)
• Increaseinmalformationratemainlyduetounderlying
infertility of the couple • Zhu, 2006, XXX
ESHRE 2019
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PERINATAL OUTCOME
Malformations in ART children in organ systems
Crude analysis
Gastro‐intestinal malformations
Uro‐genital malformations
Abdominal wall defects
Congenital heart malformations
Uro‐genital malformations
OR
1.25
1.36
1.97
1.20
1.49
CI 95%
1.06 – 1.49
1.18 – 1.57
1.48 ‐2.61
1.00 – 1.45
1.01 ‐ 2.20
Gastro‐intestinal malformations 1.56 1.15 ‐ 2.14
CoNARaS data ‐ Henningsen et al. , O‐326 ASRM‐2013
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PRECONGRESS COURSE 01 I VIENNA, AUSTRIA – 23 JUNE 2019 141
