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Testicular growth in puberty reflects spermatogenetic recovery after pediatric HSCT
25 20 15 10
5 0
15 ml
ROC
Testicular volume vs non-azoospemia
P<0.001
TBI Busulfan Cyclo
Follow up 13 ± 4.8 y, median age at study 22 ± 6.0 years, n=106 Mean adult testicular size is >15 ml after
18 ml 16 ml 9 ml
• •
busulfan-based regimes cyclophosphamide alone as conditioning
→ suggest very long-term recovery of spermatogenesis after chemotherapy- based HSCT regimens in children
Wilhelmwswswo.nheltsainl kPi.BfiC/ylio2p0i1s4to;61:1094-100.26.5.2018 15
Spermatogenetic recovery after pediatric HSCT is progressive
Follow up 16.1 ± 5.7 y, median age at study 26.1 ± 6.3 years
Preliminary HSCT data Helsinki-cohort, n=41 with no testosterone replacement
No irradation to testis Testis exposed to irradiation
Time from HSCT/years Time from HSCT/years
www.helsinki.fi/yliopisto 26.5.2018 16
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PRECONGRESS COURSE 16 I BARCELONA, SPAIN – 1 JULY 2018 59
Total sperm count/milj
Total sperm count/milj
ml
