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Gaps in knowledge 1
Fertility data matures slowly and reflects the past therapies
2010 2020 2030 2040 Puberty
Early fertility
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Final fertility
•
• •
Gaps in knowledge Impaired spermatogenesis
Risks of, and dose thresholds, for impaired spermatogenesis of
‒ Busulfan,chlorambucil,ifosfamide,melphalanandthiotepa ‒ Dacarbazine,temozolomide
‒ Carboplatin,cisplatin
‒ Carmustine,lomustine
No data on treosulfan (widely used to replace busulfan) No data on modern targeted therapy
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PRECONGRESS COURSE 16 I BARCELONA, SPAIN – 1 JULY 2018 61
