Page 57 - Eshre 2018
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Recovery of spermatogenesis depends on the dose of irradiation
≥0,1 Gy
The differentiating spermatogonia are killed → short term cessation of spermatogenesis
2–3 Gy
Kills also SSCs → long term azoospermia.
>6 Gy
Able to deplete the SSCs pool →permanent/long term infertility
Time to recovery
Time to onset of azoospermia
Stage of germ cells damaged
Radiation dose /Gy
www.helsinki.fi/yliopisto
26.5.2018 11
Sperm quality after spermatogenetic recovery
• The recovery is almost always progressive, and significant declines in sperm counts are rare
• Many recover to normospermic levels
• When the human testis contains <3–4 million sperm, sperm do not survive epididymal transit and do not reach the ejaculate
• It is possible that some sperm are produced in the testis.
• Recovery may be patchy.
• Spermatozoa can be retrieved from the testes by microdissection testicular sperm extraction (TESE)
Osasto / Henkilön nimi / Esityksen nimi www.helsinki.fi/yliopisto 26.5.2018 12
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PRECONGRESS COURSE 16 I BARCELONA, SPAIN – 1 JULY 2018 57
