Page 55 - Eshre 2018
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Who will recover spermatogenesis?
Low risk of subfertility
>70% of all childhood cancer cases
• • • • • •
• •
AML and ALL
Low risk NHL
Renal tumors, no radiotherapy Soft tissue sarcoma, low stage Germ cell tumors, no radiotherapy Brain tumors
surgery only
cranial irradiation <24 Gy dose
www.helsinki.fi/yliopisto
26.5.2018 7
Effects of low dose cancer therapy in children and adult testis
Children Adults
Adult men
• Low doses kill differentiating spermatogonia
• Surviving spermatocytes and spermatids, continue maturation into sperm
→ some sperm production 4-10w (do not cryopreserve!)
→ short term loss of sperm production and recovery at w12
Children
• No morphological effects www.helsinki.fi/yliopisto
Hou, Thesis 2007
Ad Ad
SC
Ad Ad Ap
SC
BS Spd Std
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PRECONGRESS COURSE 16 I BARCELONA, SPAIN – 1 JULY 2018 55
