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Learning Objectives
• What factors contribute to impaired spermatogenesis?
• How does spermatogenetic recovery occur after low and high dose
exposures?
• What is the effect of follow-up time for spermatogenetic recovery?
• What are the future challenges?
International Harmonisation Group / PCSF-WP6, Male Gonadotoxicity Guidelines Group
NORDFERIL Nordic centre for fertility preservation
www.helsinki.fi/yliopisto 26.5.2018 3
What factors contribute to impaired spermatogenesis?
Risk of long term/permanent infertility is associated with treatment with Alkylating agents
• Cyclophosphamide
• Nitrogen mustard
• Procarbazine van Beek et al. Hum Reprod. 2007;22:3215-3222
→ Sperm concentration decreases with increasing dose
→ No threshold dose for azoospermia can be identified genetic susceptibility to subfertility? Green et al. Lancet Oncol 2014;15:1215-1223
Skinner et al. Lancet Oncol 2017; 18: e75–w9w0w.helsinki.fi/yliopisto
Lopez Andreu et al. Pediatr Hematol Oncol. 2000;16:21-30.
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PRECONGRESS COURSE 16 I BARCELONA, SPAIN – 1 JULY 2018 53
