Page 58 - Eshre 2018

Acute depletion of spermatogonia and recovery after leukemia therapy
Age/y
Spermatogonial quantity in testicular samples at the end of leukemia therapy
Years after biopsy
No difference in total sperm counts after a follow-up period of 9-19 years between non-alkylating vs alkylating therapy
Poganitsch-Kwowrhwo.hnelnsientkai.lfiL/yeliuokpeismtoia 2017;31:1460-1463.
CED/mg/m2
Spermatogenetic recovery after HSCT in adults
Recovery of spermatogenesis after allogeneic HSCT is predicted by • younger age (<25 years)
• a non–total body irradiation (TBI) -based conditioning regimen
• no cancer therapy before HSCT
• no chronic graft-versus-host disease
Cyclophosphamide 90%
Cyclophosphamide 50% + busulphan or thiotepa
Cyclophosphamide 17% +TBI
Adapted from Anserini et awl. wBwon.heeMlsainrkroi.wfi/yTliroapnisptolantation 2002;30:447-451
Rovó et al. Blood 2006:108:1100-1105
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Percentage proportion of non-azoospermic sample Spg/cross Spermatogonia/cross
Total sperm count/milj