Page 55 - PCC08

Chromosome 11 Predicted Pathway Analysis
Trisomy 11
Monosomy 11
Trisomy 11 Categories
Cell Death and Survival Cell Death and Survival Gene Expression
Disease or Function Annotation
cell death of tumor cell lines
p‐Value 9.22E‐10 1.46E‐09
Predicted Activation Status Increased Increased
Activation z‐score 3.570 2.823
Monosomy 11 Categories
Cell Death and Survival Cell Death and Survival
Disease or Function Annotation
p‐Value 1.61E‐09 4.03E‐09 5.49E‐09 2.13E‐08 1.76E‐07 2.06E‐07 2.95E‐07 4.10E‐07 4.89E‐07 6.29E‐07 6.37E‐07 6.98E‐07 1.07E‐06 1.43E‐06 2.42E‐06 2.68E‐06 2.93E‐06 4.49E‐06 8.31E‐06 9.06E‐06 1.01E‐05 1.44E‐05 1.47E‐05 1.48E‐05 1.49E‐05 1.51E‐05 1.58E‐05
Predicted Activation Status Increased Increased Increased
Increased Increased
Decreased
Decreased Decreased Increased
Decreased Decreased
Increased
Activation z‐score 3.431 4.475 3.079 0.118 4.123 2.599 ‐1.115 ‐1.715
Cell Death and Survival Gene Expression
Cell Death and Survival Gene Expression Gene Expression
Cell Death and Survival
Cell Cycle
Gene Expression
Cell Death and Survival
RNA Post‐Transcription
Cell Death and Survival
Cell Death and Survival
Cell Death and Survival
Cell Death and Survival
Cancer, Cell Death and Survival Cell Death and Survival
Cellular Growth and Proliferation Cancer, Organismal Injury
Cell Death and Survival
Cancer, Organismal Injury
Cell Cycle
Cellular Development
Cellular Growth and Proliferation Cell Death and Survival
necrosis
4.97E‐08 6.25E‐08 9.27E‐08 2.14E‐07 7.13E‐07 9.70E‐07 6.11E‐06 7.07E‐06 1.21E‐05 1.49E‐05
Increased
Increased Decreased
Increased
2.760 Protein Synthesis
‐0.737 Cancer, Cell Death and Survival 2.012 Cancer, Organismal Injury ‐2.146 Cell Death and Survival
‐1.672 Gene Expression
2.454 Cancer, Organismal Injury 0.148 Cancer, Organismal Injury ‐1.616 Cancer, Organismal Injury 1.512 Cell Death and Survival
metabolismof protein
Trisomy 15
Monosomy 15
Trisomy 15
Categories
Gene Expression
Gene Expression
Gene Expression
Gene Expression
Gene Expression
Cellular Growth and Proliferation Dermatological Disease
Cell Death and Survival Cancer, Organismal Injury Organismal Survival
Cell Cycle
Cancer, Organismal Injury Cell Death and Survival Cancer, Organismal Injury Cell Cycle, Cell Morphology Cancer, Organismal Injury Cancer, Endocrine System Gene Expression
Cell Morphology
Cancer, Endocrine System Cellular Assembly
Cancer, Endocrine System Cancer, Organismal Injury Cell Morphology
Cell Death and Survival Cancer, Organismal Injury Skeletal and Muscular System
Disease or Function Annotation
expression of RNA 3.90E‐08
Activation z‐score ‐2.722 ‐3.244
Monosomy 15 Categories
Cell Cycle, Connective Tissue Cell Death and Survival
p‐Value 5.21E‐05 7.65E‐05 9.12E‐05 1.83E‐04 2.24E‐04 2.24E‐04 2.32E‐04 2.70E‐04 3.02E‐04 3.60E‐04 4.78E‐04 6.06E‐04 6.77E‐04 7.37E‐04 7.37E‐04 7.37E‐04 8.26E‐04 9.28E‐04 9.64E‐04 1.00E‐03 1.01E‐03 1.17E‐03 1.29E‐03 1.37E‐03 1.42E‐03 1.53E‐03 1.53E‐03
Predicted Activation Status
Decreased
Increased
Increased
Activation z‐score
1.754 0.609 ‐3.574
‐1.698 ‐1.688 ‐0.040 2.821
1.511 ‐1.529
‐0.124 ‐0.124
1.489 2.782
‐1.156
McCallie et al, 2016
C
i
e
cell death
necrosis
transcrip
A
ap
e
ration
e
l
cell
es
opt
T
a
n
s
c
i
os
Cell death
Cell death
expression of TNA
4.50E‐08 ‐1.763 Cell Death and Survival cell death of tumor cell lines
ptosis
apoptosis of tumor cell lines transcription
transcription of RNA
apoptosis
cell cycle progression
activation of DNA endogenous promoter cell death of carcinoma cell lines processing of RNA
A
cell death of fibroblast cell lines transcription of DNA
breast cancer
malignant solid tumor mammarytumor
cell death of connective tissue cells
A
t
l
P
tion
of DN
ce
a
cells
is of
lun
p
r
o
o
gca
o
nce
p
apoptosis of fibroblast cell lines
proliferation of cells
malignant solid tumor
apoptosis of cervical cancer cell lines cancer
mitosis
cell proleration of tumor cell lines colonyformation
cell viability of stemcells
de
lls
r
r
tion
ath
of m
cell death of tumor cells
Increased Decreased
Decreased
ela
nom
&&
l
rc
i
e
f
lll
ines
2.27E‐05
b
Gene Expression
1.787 Cancer, Organismal Injury
expression of RNA
1.541 ‐0.360 ‐0.878 ‐2.006
1.000 ‐2.084 ‐4.185 2.322 ‐0.487 ‐2.348 0.123 ‐2.630 0.591
3.582 0.905 0.895
&&
r
cell death of lung cancer cell lines 2.78E‐05 1.212 RNA Post‐Transcription processing of RNA
apoptosis of carcinoma cell lines
3.71E‐05 4.28E‐05 5.04E‐05 5.07E‐05 5.21E‐05 6.61E‐05 6.66E‐05 6.68E‐05 8.06E‐05 8.15E‐05 1.03E‐04 1.08E‐04
1.906 Gene Expression
1.516 Cellular Growth and Proliferation 2.840 Cell Death and Survival
‐0.941 Cell Cycle
‐3.327 Gene Expression
1.382 Cancer, Organismal Injury
0.539 Gene Expression
1.804 Cancer, Organismal Injury
‐0.321 Protein Degradation
‐2.721 Cell Death and Survival
‐1.187 Protein Synthesis
Protein Degradation
activation of DNA endogenous promoter
ac
transcription of RNA
2.61E‐07 6.00E‐07 4.41E‐06 4.63E‐06 9.78E‐06 1.19E‐05 1.37E‐05 1.63E‐05 1.99E‐05 2.19E‐05 5.12E‐05 6.51E‐05 6.84E‐05 9.43E‐05 9.54E‐05 9.97E‐05 1.17E‐04 1.44E‐04 1.52E‐04 1.57E‐04 1.59E‐04 1.60E‐04 1.95E‐04 2.32E‐04
Decreased ‐3.070 Decreased ‐2.323 Decreased ‐2.838
Increased 2.015
Increased 6.398 0.000
Increased 3.357
‐1.299
0.895 Increased 2.767
Cellular Growth and Proliferation Cellular Function
Organ Morphology
Cellular Growth and Proliferation Cellular Growth and Proliferation Cancer, Organismal Injury
Cell Death and Survival Embryonic Development
Cell Death and Survival
Cellular Development Neurological Disease
Cellular Growth and Proliferation Cell Cycle
Cancer, Organismal Injury Post‐Translational Modification Cancer, Organismal Injury
Cell Cycle
Cell Death and Survival
Cell Death and Survival
Cancer, Hematological Disease Gene Expression
Cancer, Hematological Disease Cellular Development
DNA Replication, Recombination
proliferation of cells
ell
lin
i
ion
apoptosis of tumor cell lines
cell cycle progression
Chromosome 15 Predicted Pathway Analysis
Cell Proliferation
Cell Proliferation
transcription 1.14E‐07
cell death of tumor cell lines
transcription of DNA proliferation of cells
chronic psoriasis
cell death of tumor cell lines breast or ovarian cancer organismal death
respiration of embryonic cell lines size of mammary alveolus colonyformation
colony formation of cells tumorigenesis of tissue
Cell death
cell death
mucinous neoplasm
morhplogy of chromosomes
invasive breat carcinoma
mucinous ovarian cancer transactivation of RNA
abnormal morphologyofnucleus ovarian cancer and tumors
formation of chromosome components ovarian cancer
mammary tumor morphologyofnucleus
necrosis
breast cancer
chondrogenesis
Cell death
cell cycle progression
development of brainstem
breast or ovarian cancer
apoptosisoftumor cell lines
& Necrosis
&
p‐Value
Predicted Activation Status Decreased Decreased
Disease or Function Annotation
arrest in G2/M phase transition of fibrobalsts
activation of DNA endogenous promote 2.21E‐07 Decreased ‐3.122 Cancer cell transformation &&
Transcription
Transcription
cell death
Page 49 of 102
Cel
P
T
cell death
p
l
o
f
ration
ll de
s
ath cancer
ofo
reas
ro
p
tor
ova
life
r
rat
of
ce
o
rian
c
p
ste
l
proliferation of f
an
ption
transcription of RNA
tumorigenesis of tissue
transcription
neoplasiaofepithelial tissue stabilization of protein apoptosis
translation
catabolismof protein
r
a
n
s
c
r
os
ce
AIDSdementiacomplex
arco
s
m
i
ibroblast cell lines
Necrosis
doubling time of cells
exit fromMphase neoplasiaofepithelial tissue autoubiquitination of protein epithelial cancer
arrest in G2/M phase transition apoptosis of breast cancer cell lines necrosis
recurrent acute leukemia repression of RNA
relapsed acute leukemia chondrogenesisofmesenchymal stemcells excision repair of DNA fragment
PRECONGRESS COURSE 08 I BARCELONA, SPAIN – 1 JULY 2018 55
McCallie et al, 2016