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Transcriptome Validation – Aneuploidy 11
1.400 1.200 1.000 0.800 0.600 0.400 0.200 0.000
PPIA (HSK)
CCND3
* **
EHMT2 POU5F1 (OCT4) SRPK1 Genes
Euploid (Donor)
Trisomy 11 Monosomy 11
n=30, *p < 0.05
**
*
**
Both trisomy 11 and monosomy 11 embryos are developmentally compromised compared to euploid.
McCallie et al, 2016
POU5F1 (OCT4)
Page 50 of 102
• Transcription factor, required for establishment of embryonic stem cells.
• Reprograms somatic cells to pluripotency.
• Required for epiblast and primitive
endoderm.
• Decreased expression has negative consequences on the developmental potential of an embryo.
Development. 2014 Mar;141(5):1001-10. doi: 10.1242/dev.096875. Epub 2014 Feb 6.
19
56
Normalized Fold Change
