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AR expression in 19w human fetal ovary
AR+ve somatic cells surround clusters of germ cells
Richard Anderson; in Fowler et al, Development of Steroid Signaling Pathways during Primordial Follicle Formation in the Human Fetal Ovary J Clin Endocrinol Metab, 2011 96 1754-62
Evidence for genetic basis of polycystic ovary syndrome
• Familial clustering of cases
• Concordance greater in identical than in non-
identical twin pairs (tetrachoric correlation 0.71 vs 0.38; estimated genetic influence 79%, environment 21%; Vink et al, 2006)
• Heritability of endocrine and metabolic features (Legro et al, 1998, 2002; Franks et al, 2008)
Mode of inheritance uncertain. Complex
endocrine disorder (like type 2 diabetes) likely to
be oligogenic or polygenic (Franks et al, 1997; Urbanek et al, 2007)
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