Page 32 - PCC07
P. 32
Lack of genetic heterogeneity between NIH and Rotterdam diagnostic criteria
• Onlyonelocus, GATA4/NEIL2, showed significant heterogeneity between different diagnostic criteria
Summary of GWAS Consortium Meta-analysis
• Significant genetic correlations between PCOS and obesity, fasting insulin, type 2 diabetes, high-density lipoprotein and triglyceride levels, coronary artery disease and menarche timing.
• PCOS susceptibility variants were also associated with hyperandrogenism, gonadotropin regulation and testosterone levels in affected women.
Day et al (unpublished data)
Page 25 of 196
32
