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Developmental origin of PCOS
genetic predisposition to secrete excess androgen
activation prenatally, in infancy & at puberty LH
Testosterone
insulin resistance/hyperinsulinaemia
Diet
anovulation
Maternal environment
genes regulating • follicle development
• steroidogenesis
Analysis of control human fetal ovaries during the third trimester: morphology and immunohistochemical localization of P450c17
Cole, B. et al. J Clin Endocrinol Metab 2006;91:3654-3661
Copyright ©2006 The Endocrine Society
genes regulating • insulin secretion • insulin action
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PRECONGRESS COURSE 07 I BARCELONA, SPAIN – 1 JULY 2018 29
