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Developmental origin of PCOS: an hypothesis
• Polycystic ovary syndrome is a genetically- determined, primary ovarian disorder resulting in excess androgen production
• The capacity to secrete excess androgens begins in fetal life
• Typical clinical and biochemical features of PCOS are “downstream” effects of exposure to androgen excess at or before puberty
• Phenotype may be influenced by other genes and by environment
Abbott, Dumesic & Franks, J Endocrinol 2002, 174 1-5
What is the evidence that prenatal exposure to excess androgen can lead to development of PCOS?
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PRECONGRESS COURSE 07 I BARCELONA, SPAIN – 1 JULY 2018 27
