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Biomarkers from urine (2)
Liu E et al. Cochrane Database Syst Rev. 2015 (12):CD012019
- Five studies evaluated the diagnostic value of four urinary biomarkers for endometriosis
- Three biomarkers distinguished women with and without endometriosis (enolase 1 (NNE); vitamin D binding protein (VDBP); and urinary peptide profiling by MALDI-TOF-MS proteomics)
- Authors conclusions:
- “There was insufficient evidence to recommend any urinary
biomarker for use as a replacement or triage test in clinical practice for the diagnosis of endometriosis. Several urinary biomarkers may have diagnostic potential, but require further evaluation... Laparoscopy remains the gold standard.”
Non-invasive biomarkers | Prof. Dr. Martin Götte Merck/Sigma-Aldrich
Biomarkers from blood (1)
Nisenblat V et al. Cochrane Database Syst Rev. 2016 May 1;(5):CD012179.
- Evaluation of the diagnostic accuracy of blood biomarkers for the diagnosis of peritoneal, ovarian and deep infiltrating pelvic endometriosis compared to surgical diagnosis
- Assessment of the diagnostic utility of biomarkers that could differentiate ovarian endometrioma from other ovarian masses
- Meta analysis of 141 studies on 15,141 participants and 122 blood biomarkers
- Predetermined criteria for a clinically useful imaging test : sensitivity ≥ 94%, specificity ≥ 79%
- Criteria for triage tests : sensitivity ≥ 95% and specificity ≥ 50%, SnNout test or at sensitivity ≥ 50% with specificity ≥ 95%, SpPin test.
Non-invasive biomarkers | Prof. Dr. Martin Götte
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