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Potentially relevant diagnostic factors my not be significantly different in blood, but in other body fluids
Henze D et al. Endometriosis Leads to an Increased Trefoil Factor 3 Concentration in the Peritoneal Cavity but Does Not Alter Systemic Levels. Reprod Sci. 2017 Feb;24(2):258-267.
– Study on secreted protein TFF3, a milk protein with possible signaling function, in peritoneal fluid (PF) from 50 women and serum from 124 women with or without endometriosis.
PDB
– Levels of TFF3 in PF of women with endometriosis were significantly increased ( P < .05) and correlated with local levels of CA-125, CA-19-9, IL-8, MCP-1 and MMP-7.
–TFF3 was increased during early stages of endometriosis in a mouse model.
– TFF3 was not significantly elevated in serum of endometriosis patients, but correlated with the menstrual cycle phase.
Non-invasive biomarkers | Prof. Dr. Martin Götte
Non-invasive imaging (1)
Cochrane analysis Nisenblat V et al. Cochrane Database Syst Rev. 2016 Feb 26;2:CD009591
- Comparison of diagnostic accuracy of imaging modalities for diagnosis of pelvic endometriosis, ovarian endometriosis and DIE versus surgical diagnosis
- Evaluation as a replacement tests for diagnostic surgery and as triage tests for assisting decision making regarding diagnostic surgery for endometriosis (meta analysis of 49 studies involving 4807 women)
- Predetermined criteria for a clinically useful imaging test : sensitivity ≥ 94% , specificity ≥ 79%
- Criteria for triage tests : sensitivity ≥ 95% and specificity ≥ 50%, SnNout test or at sensitivity ≥ 50% with specificity ≥ 95%, SpPin test..
Non-invasive biomarkers | Prof. Dr. Martin Götte
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