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Non-invasive imaging for the diagnosis of endometriosis
- Transvaginal ultrasound and MRI allow to identify the precise anatomical localisation of some forms of endometriosis, particularly ovarian endometrioma and deep infiltrating lesions
- Disadvantages include operator-dependency, requirement for specialised training, and failure to detect superficial peritoneal endometriosis
(Nisenblat V et al. 2016)
Schiffmann ML Ultraschall Med. 2014
Non-invasive biomarkers | Prof. Dr. Martin Götte
Urine as a biofluid for endometriosis diagnostics
Rahmioglu N et al. Fertil Steril. 2014 Nov;102(5):1233-43. + Can be easily self-collected, acceptable for most patients
+ can be collected in large quantities, can be analysed quickly and economically (compared to laparoscopy)
(-) potentially unknown relevance of the molecules excreted in urine to disease
(-) creatinine needs to be measured to determine urine concentration, as this varies substantially within individuals over time
(-) menstrual cycle may influence urine composition
(-) presence of host cells (e.g., harboring viruses) or bacterial cells is a potential source of contamination that can influence the metabolic profile
* 24h or overnight urine preferred source, short term storage 4C, long-term -80C
Non-invasive biomarkers | Prof. Dr. Martin Götte
Merck/Sigma-Aldrich
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