Page 36 - PCC03

Non-invasive Biomarkers
–non-invasive: a procedure that does not involve penetration of skin or physical entrance to the body (McGraw-Hill Dictionary of Medicine 2006; The Gale Encyclopedia of Medicine 2008).
–Biomarker categories (Nisenblat V et al. Cochrane Database Syst Rev. 2016 Feb 26;2:CD009591):
1.Replacement: replacing an existing test by having more accuracy, or a similar accuracy with other advantages.
2. Triage: used as an initial step in a diagnostic pathway to identify the group of individuals who need further testing with an existing test.
3. Add-on: used in addition to existing testing to improve diagnostic performance.
Non-invasive biomarkers | Prof. Dr. Martin Götte
Biomarker terminology – sensitivity and specificity
False positive rate (1 - specificity)
Non-invasive biomarkers | Prof. Dr. Martin Götte
36
Page 30 of 55
True positive rate (sensitivity)