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Non-invasive imaging (2)
Cochrane analysis Nisenblat V et al. Cochrane Database Syst Rev. 2016 Feb 26;2:CD009591
- The most studied modalities were transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI) (other tests could not be statistically evaluated)
- TVUS in endometrioma qualified as SpPin triage test (sensitivity 0.93, specificity 0.96)
- MRI in endometrioma met the criteria for a replacement and SnNout triage test (sensitivity 0.95, specificity 0.91)
- TVUS and MRI approach criteria for SpPin triage test (sensitivity 0.79, specificity 0.94) and a replacement and SnNout triage test (sensitivity 0.94, specificity 0.77), respectively.
- Author’s conclusions: “None of the evaluated imaging modalities were able to detect overall pelvic endometriosis with enough accuracy that they would be suggested to replace surgery.“
Non-invasive biomarkers | Prof. Dr. Martin Götte
Biomarkers from urine (1)
Liu E et al. Cochrane Database Syst Rev. 2015 (12):CD012019
- Evaluation of the diagnostic accuracy of urinary biomarkers for the diagnosis of pelvic endometriosis compared to surgical diagnosis
- Assessment of the diagnostic utility of biomarkers that could differentiate ovarian endometrioma from other ovarian masses
- Meta analysis of 8 studies involving 646 women
- Predetermined criteria for a clinically useful imaging test : sensitivity ≥ 94% , specificity ≥ 79%
- Criteria for triage tests : sensitivity ≥ 95% and specificity ≥ 50%, SnNout test or at sensitivity ≥ 50% with specificity ≥ 95%, SpPin test.
Non-invasive biomarkers | Prof. Dr. Martin Götte
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