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Biomarkers from blood (4)
Gajbhiye R et al. Panel of Autoimmune Markers for Noninvasive Diagnosis of Minimal-Mild Endometriosis. Reprod Sci. 2017 Mar;24(3):413-420
– Validation of ELISAs for epitopes of a panel of autoimmune markers as serum markers for minimal-mild endometriosis (rAFS stage I-II).
– Cross-sectional multicenter study on rAFS stage I-II patients [n = 133]) and healthy controls (n = 104)
–The sensitivity of 6 biomarkers (anti-TMOD3b-autoAb, anti-TMOD3c- autoAb, anti-TMOD3d-autoAb, anti-TPM3a-autoAb, anti-TPM3c-autoAb, and anti-TPM3d-autoAb) was higher at the specificity of ≥80% for diagnosis of rAFS stage I to II endometriosis as well as ultrasound- negative endometriosis (sensitivity 67-76%).
Non-invasive biomarkers | Prof. Dr. Martin Götte
Biomarkers from blood (5)
Brubel R et al. Serum galectin-9 as a noninvasive biomarker for the detection of endometriosis and pelvic pain or infertility-related gynecologic disorders. Fertil Steril. 2017 Dec;108(6):1016-1025.e2
–Prospective case-control study on serum levels of the immunomodulator galectin-9 (by ELISA) of 77 endometriosis patients, 28 gynecologic controls, and 30 healthy women.
– Significantly elevated Gal-9 levels were found in both minimal-mild (I– II) and moderate-severe (III–IV) stages of endometriosis in comparison with healthy controls.
– At a cutoff of 132 pg/mL, ROC analysis revealed an excellent diagnostic value of Gal-9 ELISA with a sensitivity of 94% and specificity of 93.75%.
Non-invasive biomarkers | Prof. Dr. Martin Götte
PDB
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