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Combination of noninvasive biomarkers (1)
Nisenblat V et al. Cochrane Database Syst Rev. 2016 Jul 13;7:CD012281
- Evaluation of the diagnostic accuracy combination of non-invasive tests for the diagnosis of pelvic endometriosis (peritoneal and/or ovarian or deep infiltrating) compared to surgical diagnosis as a reference standard
- Meta analysis of eleven eligible studies including1339 participants.
- Predetermined criteria for a clinically useful imaging test : sensitivity ≥ 94%, specificity ≥ 79%.
- Criteria for triage tests : sensitivity ≥ 95% and specificity ≥ 50%, SnNout test or at sensitivity ≥ 50% with specificity ≥ 95%, SpPin test.
Non-invasive biomarkers | Prof. Dr. Martin Götte
Combination of noninvasive biomarkers (2)
Nisenblat V et al. Cochrane Database Syst Rev. 2016 Jul 13;7:CD012281
Tests that met the criteria for a replacement test were:
- a combination of serum IL-6 (cut-off >15.4 pg/ml) and endometrial PGP 9.5 for pelvic endometriosis (sensitivity 1.00, specificity 0.93) and the combination of vaginal examination and transvaginal ultrasound (TVUS) for rectal endometriosis (sensitivity 0.96, specificity 0.98).
Tests that met the criteria for SpIN triage tests for pelvic endometriosis were:
- A multiplication of urine vitamin-D-binding protein (VDBP) and serum CA-125 (cut-off >2755) (sensitivity 0.74, specificity 0.97)
- A combination of history (length of menses), serum CA-125 (cut-off >35 U/ml) and endometrial leukocytes (sensitivity 0.61, specificity 0.95)
Non-invasive biomarkers | Prof. Dr. Martin Götte
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