Page 125 - PCC02
P. 125
Ch2OH
I
CpG
4
CH2OH CH2OH CH2OH
Cytosine oxidation and demethylation (TET)
Active de‐Methylation
Demethylation TET
Nuclear bases
• It is important to have “clean” bases in order to allow a reliable DNA repair (oxidized bases!!!).... at least C and G
• “A defective brick makes a defective wall”
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PRECONGRESS COURSE 02 I BARCELONA, SPAIN – 1 JULY 2018 125
