Page 124 - PCC02

Methylation and gene expression
transcription
1 CpG
2 CH3 I
CpG
TF binding
CGCGCGCG
promoter
TF no binding
CGCGCGCGCG I I I
CH3 CH3 CH3
Hydrophylic interaction: Binding
Lipophylic (Hydrophobic) Nointeraction
CH3CH3, CH3 CH3
IIII
TF transcription factor
The most affected base is guanine, thus affecting the CpG islands ( and the telomeres)
The important zones of genes expression/regulation linked to epigenetic regulation are disturbed by oxidation
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