Page 37 - PRECONGRESS COURSE 04

3. Mechanisms & endocrine control
3.1. Animal models (rodents)
Estrogen influence on WOI was recapitulated in other studies
• COUP‐TFII NULL MICE (Lee et al. 2010)
o infertile(failureinblastocystattachment)
o increasedestrogensignalling
o asynchronyembryocompetency/uterinereceptivity o reduced length of the WOI
o shifted in the WOI
o rescued by treatment with a pure anti‐estrogen
Measuring and enhancing endometrial receptivity to improve pregnancy outcomes
23
3. Mechanisms & endocrine control
Uterine ablation of the BMP* type 1 receptor activin-like kinase 3 (ALK3/BMPR1A) Increase of estrogen markers
Decreased expression of implantation markers
* Bone morphogenetic proteins (TGF-β family members) relevant in all phases of implantation and pregnancy
Monsivais et al. 2016
Measuring and enhancing endometrial receptivity to improve pregnancy outcomes
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PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 37
controls
ALK3cKO
controls
ALK3cKO
ALK3cKO
controls
controls
ALK3cKO
ALK3cKO
controls ALK3 cKO
controls
controls
ALK3cKO