Page 35 - PRECONGRESS COURSE 04

3. Mechanisms & endocrine control 3.1. Animal models (rodents)
LH
Proestrous 1
Luminal epithelium
Stroma cells
Robertshaw, et al. 2016
Wang and Dey 2006, Zhang, et al. 2013
2 3
Muc-1
PR ERα
COUP TF II
PR ERα
4
5 6
days of pregnancy
degeneration luminal epithelium
stroma cell decidualisation
20
PRE-RECEPTIVE WOI
Post-receptive
progestrone
estradiol
LH
Proestrous 1
Luminal epithelium Stroma cells
Robertshaw, et al. 2016 Measuring and enhancing endometrial 19 Wang and Dey 2006, Zhang, et al. 2013 receptivity to improve pregnancy outcomes
3. Mechanisms & endocrine control 3.1. Animal models (rodents)
2 3 4
Muc-1
5 6
days of pregnancy
degeneration luminal epithelium
stroma cell decidualisation
blastocyst attaches to luminal epithelium
epithelium degeneration (trophoblast entosis & apoptosis) stromal cell proliferation & decidualisation
1.
2.
3.
‐ ESTRADIOL surge at day 4: OVX mice on day 4 fail implantrescued by estradiol
evening 4th day:
PRE-RECEPTIVE
WOI
embryo
Post-receptive
progestrone
estradiol
Measuring and enhancing endometrial receptivity to improve pregnancy outcomes
embryo
PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 35