Page 33 - PRECONGRESS COURSE 04

2 WOI: search for novel markers
2.4 The future1 : Proteomics and Secretomics
Garrido-Gomez, et al. 2014
Measuring and enhancing endometrial receptivity to improve pregnancy outcomes
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2 WOI: search for novel markers
2.4 The future1 : Proteomics and Secretomics
- First studies in '80s: variations of ions and proteins (single) throughout cycle - Secretome is a complex matrix
proteins, amino acids, electrolytes, glucose, urea, cytokines, growth factors, metalloproteinases and their inhibitors, immunoglobulins, a-1 antitrypsin precursor, haptoglobin, and transferrin
- mediators of endometrial receptivity
- maintenance and nurturing of ascending spermatozoa - maintenance and nurturing of pre-implantation embryo
MAJOR ADVANTAGES
- Non-invasive
- Aspirate just prior to embryo transfer (with no effect on IVF outcome)
- Aspirate of flushing
- Secretion better represents global uterine condition compared with biopsies
Cheong et al, 2012
Measuring and enhancing endometrial receptivity to improve pregnancy outcomes
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PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 33
PGRMC1 annexin A6 (ANXA6)