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2 WOI: search for novel markers
2.3 Today in clinic: Expression profiling
ENDOMETRIAL RECEPTIVITY ARRAY (ERA): Personalised embryo transfer expression of 238 genes related to WOI
– Sensitivity: 0.99758
– Specificity: 0.8857
– Dating against LH peak: 0.922
– Reproducibility: 100%
– Superior over histological dating
Diaz-Gimeno et al. 2011 & 2014 Horcajadas et al. 2008; Mahajan 2015
Measuring and enhancing endometrial receptivity to improve pregnancy outcomes
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2 WOI: search for novel markers
2.3 Today in clinic: Expression profiling
NCT01954758 – Prospective, randomised, multicentre, international, open label, controlled trial
- Aim: 546 women with reproductive failure
Ad interim evaluation - 356 women
ASRM 2016 / Endometrium: from Physiology to Pathologies Fondazione International Menarini, 2016
PREGNANCY RATE / ET
- 61.7% (37/60)
- 60.8% (45/74)
- 85.7% (42/49) (P=0.003)
Measuring and enhancing endometrial receptivity to improve pregnancy outcomes
Fresh cycle - ET
Frozen ET
Frozen – pET personalised ET
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PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 31
