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4. Mechanisms & intracrine control
4.1. Intracrinology
• Term introduced in 1989 by Prof Labrie
PRE-RECEPTIVE WOI Post-receptive
• It refers to the ability of peripheral tissues to produce and
deactivate steroids using serum precursors LH
• Recent technological advances allowed progresses in the field
• Intracrinology fine tunes the steroid (estrogen) exposure in estradiol peripheral tissues
-14 -7 0 7 10 14days • It should be seen as part of the endocrine control
?
progestrone
• Intracrine unbalances associated with endometrial disease
• Infertility
• Endometriosis
• Endometrial cancer
intracrinology
Brosens, et al. 2004; Cornel et al. 2017;
Cornel et al. 2012; Delvoux et al. 2014; Measuring and enhancing endometrial
Delvoux et al. 2009; Konings, et al. 2017; receptivity to improve pregnancy outcomes 27 Labrie 1991 & 2015
4. Mechanisms & intracrine control
4.1. Intracrinology
cholesterol
CYP11A1
pregnenolone
CYP17 3βHSD
CYP17
17-OH pregnenolone
CYP17
DHEA androstenedione
3βHSD17βHSD testosterone
estrone
17βHSD1 ESTRADIOL
OVARY
Huhtinen el al. 2012 & 2014
Measuring and enhancing endometrial 28 receptivity to improve pregnancy outcomes
progesterone
17-OH progesterone
PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 39
CYP19A1
human
