Page 41 - PRECONGRESS COURSE 04

4. Mechanisms & intracrine control
4.1. Intracrinology
• Intracrine enzyme expression change during the menstrual cycle
• 17βHSD2 is induced by Progesterone in luteal phase (estradiol  estrone)
• EST is induced by Progesterone in luteal phase (estrone  estrone-sulfate)
• 3βHSD level is highest in mid-luteal phase endometrium
• Cycle / pregnancy-dependent levels shown in non-human primates
• Intra-tissue steroid level varies in a cycle-dependent way
Huhtinen el al. 2012 & 2014
Vani et al. 2007; Rhee et al 2003, Dassen et al. 2007
Measuring and enhancing endometrial receptivity to improve pregnancy outcomes
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5. Intracrinology & reproduction
5.1. Animal evidences
Measuring and enhancing endometrial Das et al, 2009 receptivity to improve pregnancy outcomes
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PRECONGRESS COURSE 04 I GENEVA, SWITZERLAND – 2 JULY 2017 41