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Vacant Kinetochore
Aurora Mps1
– Key component of SAC
Mad2 Cdc20
Cdc20
MCC Checkpoint complex
How does the SAC inhibit the APC?
Vacant Kinetochore
Aurora Mps1
Mad2 – Key component of SAC
– Upstream kinases
• Recruitment
• Amplify signal
Cdc20 MCC
Mad2 Cdc20
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PRECONGRESS COURSE 03 I GENEVA, SWITZERLAND – 2 JULY 2017 25
CHROMOSOME CHROMOSOME
