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The SAC: Kinetochore based diffusible signal
The Spindle Assembly Checkpoint (SAC)
Kinetochore
• NO MICROTUBULE ATTACHMENT
SAC signal
• KINETOCHORE RECRUITS SAC PROTEINS • MAKES INHIBITORY SIGNAL
Anaphase Promoting Complex (APC)
• APC IS INHIBITED
Anaphase
• PREVENTS ANAPHASE
Aneuploidy?
• PROTECTS AGAINST ANEUPLOIDY
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