Page 49 - ESHRE2019

1. Sequence generation +
“The random allocation sequence was generated using a random number table”
“Patients were randomly allocated to either the +
2 intervention group or control group with the use of a -
computer generated random number table”
“Patients were then randomised to either the
3 thrombolysis or control group, one after another,
1
according to the order of admission”
“Then patients were randomly, using sealed envelope, allocated into 2 equal groups”
? ?
4
5 “This is a randomised case-control study”
2. Allocation concealment
• Do not confuse with blinding during the study!
• Concealment means that when a person is recruited to the study, no-one can predict which group they will be allocated to
• Ensures the strict implementation of the random sequence • Without concealment, this is not a randomised trial.
• Participants are effectively selected into groups.
• For example, if random allocation list is posted on the clinic wall then everyone knows what is coming next (treatment or control). So can pick a patient who they think ‘should’ be in the treatment group (say).
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PRECONGRESS COURSE 17 I VIENNA, AUSTRIA – 23 JUNE 2019 47