Page 40 - ESHRE2019
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2009
•The generation and characterization of human embryonic stem cell lines stably carrying a VASA-pEGFP-1 reporter construct that expresses GFP in a population of differentiating human embryonic stem cells that show expression of characteristic markers of primordial germ cells.
2009
• Pluripotent stem cells (both hESC and iPS) give rise to in vitro PGC following 7 days of differentiation on hFGC
• They correspond to immature PGCs (developmental stage in vivo between specification and less than 9 week of gestation)
• Initiation of imprinting erasure is dependent on the epigenetic status of the pluripotent stem cell from which iPGCs are generated.
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