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HIV assessment in affected males
• 28 studies reported plasma viral load of the infected men at time of semen washing.
• 985/1890men(52.1%)werenotvirallysuppressed.
• Viralsuppressionincludedaloadof400copiesor
less/ml.
• CD4levelsreportedin21studies–averageCD4count.
= 200 - 608 cells /ml
• Only 5 studies reported on post wash semen RNA
positivity ranging from - 1.3% - 7.7 %
Ref. Maryam Zafer et.al. Fertil Steril 2016 March: 105(3) 645-655
Kato S. et. Al. AIDS 2006; 20:967-973
Duru Shah
Benefits of semen washing
• Semen washing is an effective method to prevent transmission in men who are:-.
→ Unwilling to initiate anti retroviral therapy → Non compliant to therapy
→ Not virally suppressed
• 1/3rd of men in Sub-Saharan region are not virally suppressed in spite of taking anti-retrovirals.
• 48% of men with undetectable viral load in plasma, have detectable virus in their semen
Ref. Baeten JM, et.al. Current HIV research 2003; 1: 69- 86 Duru Shah De Vincenzi I et.al. Journal of Medicine 1994; 331: 341- 346
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